Over the past decade, a growing number of studies have shown that Cannabis sativa (CBD) can protect neurons from damage and neurodegenerative disorders [6,7], although its effects on oxidative stress are still unclear. CBD is thought to exert neuroprotective properties by restoring the balance between anti-oxidant and oxidative processes. In many neurodegenerative disorders, this ability is disrupted as shown by an increase in oxidative damage levels and a reduction of antioxidant enzymes. CBD can also bind specific receptors, increasing the activity of nrf-2/ARE. This suggests that CBD may be able promote neuroprotection through activating these pathways.
In a number of experiments, the effects of different Cannabis extracts as well as selected cannabinoids were investigated on the toxicity of an in vitro model for global ischemia of the forebrain (OGD) that affected the subregion CA1 of rat organotypic slices of the hippocampal. Our aim was to assess the role of CB1 and CB2 receptors in the neurotoxic effect of THC and CBD on OGD-induced cell death.
Our results show that the toxicity induced by 1 uM of THC on the CA1 subregion of OGD-exposed slices was completely prevented by CB1 receptor antagonists AM251, but not by CB2 receptor antagonists AM630, and a selective CB1 antagonist WAY-100635, whereas CBD showed a significant neuroprotective effect against OGD-induced cell death in the CA1 subregion of OGD-exposed rat organotypic hippocampal slice only by co-incubation with a TRPV2 antagonist tranilast and a 5HTA1 antagonist WAY-100635 and a PPARg antagonist G3335. The CB1-antagonist AM251 did not prevent the neuroprotective activity of CBD at 10 uM. However, the TRPV2-antagonist tranilast and the 5-HT1A-antagonist WAY-100635 as well the PPARg-antagonist G3335, did.
FAQ
Are CBD companies worth the investment?
This depends on your needs. They can be a great investment if it is money you are after. If however, you only want to invest in something that may help others, then no.
How does the price of CBD vary across different states?
Prices for CBD products can vary depending on where you live. You can even find prices that are more than 10 times higher in some places!
The prices go up the further you go north. CBD in Alaska costs $35 per gram. In Hawaii, however, it costs about $200 per gram.
This trend continues throughout the country. The prices range from $5 to more than $2,500 per gram.
This is what's the deal?
The varying levels and regulations of cannabis regulation are one reason prices can vary widely. Some states require CBD products to contain minimal THC (the psychoactive element of marijuana). Other states don't care what level of THC is present.
Some companies may choose to sell their products first in one state before shipping them to another.
What is the size of the global CBD market?
The global CBD market was valued at $US 3.5 billion in 2015, according to Euromonitor International. This is more than 10% higher than 2014
The report projects that this figure will reach $US6.4 billion by 2020. This represents an average annual growth rate 12%.
CBD products will make up around half of all products derived from hemp by 2020.
This includes CBD oils, as well other CBD products, including food, beverages cosmetics, pet care, and CBD oils.
Where can I purchase CBD products?
CBD can also be purchased at your local store or online. Online retailers are more likely to offer you better deals. Many websites offer CBD products that are made from industrial hemp. This product contains less than 0.3% THC.
You can shop locally if you prefer to buy CBD products from brick-and-mortar stores.
There are laws in many states that allow CBD products to be purchased without the need of a prescription. If you live in one of those states, you may be able to buy CBD products at your local pharmacy.
CBD products may be delivered right to your doorstep.
Is the CBD industry growing?
Yes, it is! As legalization spreads throughout North America, this growth is expected continue. Canada was the first country to legalize recreational cannabis use. Several states also have medical marijuana laws.
This trend will likely continue at least another ten years, as more states adopt legislation allowing medicinal marijuana.
It is also economically sensible to legalize marijuana. As well as providing a lucrative alternative market for farmers, there are many other benefits to legalizing pot.
It could reduce crime rates, by decreasing illegal drug availability. It could also provide a source of tax revenue for governments.
People will likely choose to consume less alcohol as they become more comfortable with legal marijuana. This would result in fewer hangovers, and lower healthcare costs.
Chronic pain sufferers may find that marijuana can actually improve their quality of life. Many believe THC, the active component in marijuana, is responsible for relieving symptoms like muscle spasms or nausea that can be caused by chemotherapy.
A lot of people believe that marijuana is a good option for treating anxiety and depression. In fact, some studies suggest that marijuana can even treat schizophrenia.
Even though the CBD sector looks bright, there are still many challenges.
What CBD products do you sell most?
CBD products can be found all over these days. People are buying them for everything from anxiety to pain relief. The market is vast and growing rapidly.
What are people buying CBD for? How does this impact you as a brand manager?
Well, according to Statista, CBD products are being bought for their relaxing effects. They can also be used to treat inflammation.
This means that products with both CBD or THC can be sold both for recreational and medicinal purposes.
What about brands that focus on a specific purpose? A company selling CBD for stress relief is an example of a brand that will not be challenged.
In addition, if a brand focuses on CBD for medical purposes, then it will have a large customer base.
However, a brand that wants to target recreational customers must develop a unique selling message (USP). A USP basically refers to a unique selling point that sets a brand apart.
For example, some brands offer shipping free of charge, while others offer discounts when you order in bulk.
Is CBD a good place to invest?
The demand for hemp-based goods continues to rise as more people realize their benefits. It's estimated that by 2022 there could be $1 billion worth of hemp-based products on store shelves.
The market is also expected to continue growing at an annual rate of over 20% until 2020, when it reaches $2.5 billion.
Hemp oil has been used in many beauty products and health care products including creams, lotions.
There are also several companies producing CBD-infused beverages, snacks, pet foods, dog treats, and other food items.
CBD is currently legal in all 50 US states. This may change quickly. As more research is conducted into the potential uses of CBD, more laws will likely be passed, making it easier for businesses to operate legally.
These are just a few of the many reasons CBD investment can be lucrative.
Statistics
- While the primary injury may not be treatable, interventions that attenuate secondary sequelae are likely to be of benefit [203].Only one study (ncbi.nlm.nih.gov)
- OralWhere HED is the human equivalent dose, and Km is a correction factor estimated by dividing the average body mass (BM) of the species (60, 0.020, and 0.150 kg for 11 humans, mice, and rats, respectively) and by its surface area (see: Nair et al. (ncbi.nlm.nih.gov)
- A recent systematic review of human trials also reported that individuals with epilepsy receiving CBD (5–20 mg·kg−1·day−1) were more likely to experience decreased appetite than those receiving placebo (i.e., ~20 vs. 5% of patients) (ncbi.nlm.nih.gov)
- CBD seems unlikely to directly influence sleep in healthy humans [115] (and maybe “sleep-promoting” in those with certain comorbid conditions) (ncbi.nlm.nih.gov)
- however, one study also found that these effects were virtually abolished when the original media (a nutrient broth agar) was replaced with one containing 5% blood (increasing the minimum concentration to ~160 μM CBD) [179]. (ncbi.nlm.nih.gov)
External Links
How To
How to sell CBD Products in the United States
CBD (cannabidiol), which is one among 100+ cannabinoids that are naturally found in cannabis, is also known as THC (Tetrahydrocannabinol). It's non-psychoactive and doesn't cause "high" like THC (Tetrahydrocannabinol). CBD oil is made from hemp. It does not contain THC, unlike marijuana where there can be a wide range of THC levels.
Cannabidiol has been shown to reduce anxiety and treat depression according to studies. CBD is legal in most states. But there are limitations. Find out if you qualify here.
The first step in selling CBD products is to choose the product you want to sell. Starting with tinctures is a good option. Then you could move to topicals and oils. You might also want to make your own personal products such as lip balms and lotions. Whatever you decide to do, know this: there's a growing demand for CBD products, especially those made with whole plant extracts. You are now ready to get started!
There are many CBD products that are available today. Each type is different depending on how they were extracted, processed and made. A few popular options include:
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Topical CBD - This means that CBD is directly applied to the skin. Topical CBD is preferred by most people because it delivers faster results than oral CBD. The downside is that topical can take longer to be absorbed into the bloodstream. The best use of topical is for the treatment of pain and inflammation, rather than general wellness.
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Sublingual CBD - This is where a small amount of liquid CBD is placed under one's tongue for 60 second before swallowing. Sublingual is often claimed to be the fastest route for CBD absorption, but there are disadvantages. The first is that the sublingual route doesn't allow for acute symptoms to be treated because it is absorbed via the oral mucosa, not the digestive system. It was also found that only 10% is absorbed into the bloodstream. It can be difficult for you to calculate the exact dose using this method.
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Oral Spray/Gum uses drops of CBD dispersed in a carrier oil, such as sublingual. CBD can also be applied under the tongue, or chewed with gum. These methods can provide immediate relief, but aren’t recommended for long-term usage due to their slow rate.
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Vaporizer Pens: These devices heat CBD isolate and wax to produce vaporized CBD. They are generally more effective than either smoking CBD flowers or taking CBD capsules.
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Determine What Legal Issues May Impact Your Business
If you plan on operating an eCommerce platform, you will need to consider whether your business will operate legally throughout the United States. CBD products are regulated in the United States by the Drug Enforcement Administration. They are classified as Schedule I substances. This means that CBD products cannot be sold without a prescription from the DEA.
Every state has its own CBD product laws, in addition the federal law. New York City, California, Massachusetts, Michigan and Rhode Island have legalized medicinal marijuana. Others, like Florida, Tennessee, Kansas, Indiana, Missouri, and Oklahoma, have passed legislation allowing CBD oil derived from hemp to be sold over the counter. These states may allow you to sell CBD products without worrying about legal issues. You should still consult an attorney specializing on cannabis law if you live or work in another state that has cannabis legalization.
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Create a Plan for Marketing
Once you know what product you want to sell, you'll need to decide how to promote it. There are many options for how to do this. You can:
You can start an eCommerce Platform. You may already be familiar with selling online. If not, there are many platforms available that make it easy to set up shop. Shopify is a popular choice. It allows users create an online shop and market it via email and social media.
Hire an expert online marketer. If you don't have any previous experience running an eCommerce site, hiring someone to manage it can help save time and money. A company should offer both SEO (search engines optimization) and pay-per-click (pay-per click) services.
If you are looking for a payment processing company, make sure it offers all the security features required. For example, some processors require customers to verify their identities before processing payments. This is to prevent fraud. Other options are Square, Stripe or Square.
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Get shipping options set up
Shipping costs can add up quickly when you run an eCommerce store. This problem can be avoided by finding a provider that offers free shipping if your order exceeds $100. Many companies also offer flat rates that are dependent on order size.
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Decide Whether to Sell Products Directly From Amazon
Amazon is a reputable online marketplace that sells hundreds of thousands of items. Amazon does not allow sellers to ship directly from their site to customers. Instead, they must use third-party service providers. When you sell on Amazon, you're responsible for managing customer orders. Amazon charges fees in return for fulfillment, storage, delivery, and shipping.
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Track Customer Feedback and Sales
Your clients must provide feedback in order for you to succeed. Google Analytics is a good place to get started. This tool can be used to track traffic and sales. It also shows where visitors come from and what keywords they used to search for your website.
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You might consider selling your own brand of CBD Oil
It is possible to make your own CBD products and make a profit. Your own CBD products can be customized to suit your specific needs. You can charge more than the other retailers since you don't share any profits.
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Get Discounts and Specials
People love to save money especially when it involves health care. Promos and discounts are great ways of increasing sales. They encourage people to purchase your products.
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Use social media to market you business
Social media is an effective tool to promote your company. Facebook, Instagram, Twitter and Pinterest are just a few of the many websites that have potential customers who might be interested in your products. The key is to keep your posts relevant, interesting, and engaging.
People love to try new foods. Giving away coupons or samples can help increase sales, provided you don't do it too often. Make sure you clearly describe the cost of each sample.
Accessing the internet from mobile devices is increasing in popularity. Your website must be compatible with both smartphones and tablets. People who can't view your site on their mobile devices or tablets will leave the site and go somewhere else.